变异链球菌葡聚糖结合蛋白B的生物学特性研究进展

Research progress in biological property of Streptococcus mutans glucan binding protein B

变异链球菌是人类龋病的主要致病菌,葡聚糖结合蛋白是其重要的毒力因子之一。葡聚糖结合蛋白B在变异链球菌的致龋、维持细菌形态、发挥细胞壁生理功能等方面有重要作用,同时其N端具有免疫原性,可应用于免疫防龋。下面就葡聚糖结合蛋白B的生物学特性研究进展作一综述。

Streptococcus mutans has been implicated as a primary pathogenic agent of dental caries in human. Glucan binding proteins are thought as one of the significant causative agents. Glucan binding protein B plays an important role in cariogenic trait of Streptococcus mutans. It is also involved in cell shape and cell function of Streptococcus mutans. On the other hand, immunologic property of its amino terminus makes it possible to be used in immunization against dental caries. This review paid attention to the research progress of the biological property of glucan binding protein B.