刺猬蛋白信号通路与成骨的关系

The relationship between hedgehog signaling pathway and osteogenesis

刺猬蛋白(hedgehog)信号通路是一个在胚胎阶段调控多种组织器官发育的重要的信号通路,在成骨方面具有重要的作用。下面主要就hedgehog信号通路及其对成骨相关细胞的作用、hedgehog在骨组织发育中的作用、hedgehog基因修饰在成骨中的应用作一综述。

Hedgehog signaling pathway is an important signal pathway, which regulates the development of variety of tissues and organs in the embryonic stage. It also plays an important role in osteogenesis. This review discussed the relationship between the hedgehog signaling pathway and osteogenesis in several aspects, including the relationship between the hedgehog and osteochondral cell, the effect of hedgehog on bone development and the role of hedgehog in osteogenesis with gene therapy techniques.