带蒂皮瓣新生血管化机制中相关生长因子的作用

Function of related growth factors in the neovascularizational mechanism of pedicle flaps

带蒂皮瓣新生血管化主要有血小管发生和血管生成两种机制,其中血管生成包括内皮出芽、套叠式血管生成和血管重建术。血管内皮生长因子、碱性成纤维细胞生长因子和血小板衍生生长因子在带蒂皮瓣新生血管化机制中具有重要作用,主要涉及临时基质形成、内皮细胞活化、内皮细胞增殖、周细胞和血管平滑肌细胞募集以及毛细血管网络形成。

Two mechanisms, vasculogenesis and angiogenesis, can elucidate the neovascularization of pedicle flaps, in which angiogenesis contains endothelial sprouting, intussusceptive angiogenesis and revascularization. Some critical growth factors, such as vascular endothelial growth factor, basic fibroblast growth factor, platelet-derived growth factor, play important roles in the neovascularizational mechanism of pedicle flaps. The roles mainly involve formation of matrix, activation of endothelial cell, proliferation of endothelial cell, recruitment of pericyte and vascular smooth muscle cell, and formation of capillary network.