维持性血液透析患者血管钙化情况及其与心血管疾病的关系

Relationship of vascular calcification and cardiovascular disease in maintenance hemodialysis patients

目的调查维持性血液透析（MHD）患者血管钙化的发生情况。方法应用x线摄片方法调查MHD患者胸主动脉及四肢血管发生的钙化情况，初步分析血管钙化与心血管疾病的关系。结果69例患者中38例有至少一处血管钙化，占55％（38／69）。23例有四肢血管钙化的患者中，大部分（14／23）为内膜、中膜钙化同时存在。有血管钙化患者与无血管钙化患者相比，年龄更大，既往有缺血性心脏病的患者更多（P〈0．05）。随访1年，有16例患者在此期间发生心衰。有血管钙化患者发生心衰的人数明显多于无血管钙化患者（P〈0．01）。结论血管钙化可能与MHD患者心血管疾病有关。

Objective To observe the occurrence of vascular calcification in maintenance hemodialysis （MHD） patients. Method Sixty-nine MHD patients were enrolled in this study. Vascular calcification was evaluated by plain X-ray films of chest, upper and lower extremites. Analyzed the relationship of vascular calcification and cardiovascular disease. Results Vascular calcification on X-ray films presented in 38 cases （55%）. Of the 23 cases with calcification on arteries of extremites, 14 cases were found to have both intimal calcification and medial calcification. Patients with vascular calcification were older. Ischemic heart disease and cardiac failure appeared more frequently in the patients with vascular calcification. Conclusions Both intimal calcification and medial calcification are frequently found in the MHD patients. Vascular calcification is probablly associated with cardiovascular disease in MHD patients.