摘要
目的将在胃的癌症前期的损害的治疗调查 Weining 小粒的潜在的治疗学的效果和机制。六十只老鼠随机被分到一个空白的组或一个模型组或到的方法收到酸或高的 retinoic -- ，中等 -- 或低 -- Weining 的剂量小粒。动物的一般条件在治疗前后被遵守。在胃的 mucosal pathohistology， telomerase 活动，增长索引(PI ) 和 apoptosis 索引(AI ) 的变化被测量。结果将军调节，包括活动并且吃，与肠的组织变形(IM ) ，不正常的增生(ATP ) 或是比在模型的那些显著地低的积极 telomerase 活动组织的老鼠有的数字在所有 Weining-granule-treated 组被改进(P 【
0.05 或 P 【
0.01 ) 。与模型组相比， Weining 小粒的所有剂量显著地减少了 PI (P 【
0.01 ) 并且增加的 AI (P 【
0.05 ) 。结论 Weining 小粒可以由禁止 telomerase 活动和胃的癌症房间并且由加速他们的 apoptosis 的增长为胃的癌症前期的损害的治疗提供一个治疗学的好处。
Objective： To investigate potential therapeutic effects and mechanism of Weining granule in the treatment of gastric precancerous lesions. Methods： Sixty rats were randomly assigned to a blank group or a model group or to receive retinoic acid or high-, medium- or low- dose of Weining granule. General conditions of the animals were observed before and after treatment. Changes in gastric mucosal pathohistology, telomerase activity, proliferation index （PI） and apoptosis index （AI） were measured. Results： General conditions, including activity and eating, were improved in all Weining-granule-treated groups with the numbers of rats having intestinal metaplasia （IM）, atypical hyperplasia （ATP） or positive telomerase activity being significantly lower than those in the model group （P 〈 0.05 or P 〈 0.01）. Compared with the model group, all doses of Weining granule significantly decreased PI （P 〈 0.01） and increased AI （P 〈 0.05）. Conclusion： Weining granule may provide a therapeutic benefit for the treatment of gastric precancerous lesions by inhibiting telomerase activity and proliferation of gastric cancer cells and by accelerating their apoptosis.
