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环孢素A联合ALG治疗儿童再生障碍性贫血的临床研究 被引量：2

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摘要 儿童再生障碍性贫血（AA）发病急，病死率高，是血液病治疗的难点。近年来，随着免疫抑制治疗（IST）的广泛开展，AA的预后有了极大的改善。本科自2002年1月～2007年12月，采用环孢素A（CsA），联合抗淋巴细胞球蛋白（ALG），雄性激素方案治疗再生障碍性贫血，疗效满意，现报告如下。
作者 蒯文霞 杨晓春 李媛媛
机构地区 南京医科大学附属淮安一院儿科 南京医科大学附属淮安一院中心实验室
出处 《南京医科大学学报（自然科学版）》 CAS CSCD 北大核心 2009年第3期415-417,共3页 Journal of Nanjing Medical University(Natural Sciences)
关键词 环孢素A 抗淋巴细胞球蛋白 儿童 再生障碍性贫血
分类号 R725.5 [医药卫生—儿科]
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参考文献5

  • 1Mao P,Wang S,Wang S,et al. Umbilical cord blood transplant for adult patients with sevele aplastic anemia using anti-lymphocyte globulin and cydophosphamide as conditioning therapy [J]. Bone Marrow Transplant,2004,33 ( 1 ) :33-38
  • 2Marsh JC. Management of acquired aplastic anaemia[J]. Blood Rev,2005,19(3) : 143-150
  • 3钱新华.儿童获得性再生障碍性贫血的免疫抑制治疗[J].实用儿科临床杂志,2006,21(3):189-192. 被引量：6
  • 4oung NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastie anemia[J]. Blood, 2006, 108 (8) : 2509-2519
  • 5Marsh J,Schrezenmeier H,Martin P,et al. Prospective randomized muhicenter study comparing cyclosporine alone versus the combination of antithymocyte globulin and cyclosporine for treatment of patients with nonsevere aplastic anemi-a:a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anemia Working Party [ J ]. Blood, 1999,93 (8) : 2191-2195

二级参考文献10

  • 1Fuhrer M,Rampf U,Baumann I,et al.Immunosuppressive therapy for aplastic anemia in children:amore severe disease predicts better survival[J].Blood,2005,15,106(6):2102-2104.
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  • 3Killick SB,Marsh JC,Gordon-Smith EC,et al.Long-term out come of acquired aplastic anemia in children:comparison between immunosuppressive therapy and bone marrow transplantation[J].Br J Haematol,2000,111:321 328.
  • 4Zeng W,Nakao-S,Takamatsu H,et al.Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia:evidence for the involvement of antigen-driven T-cell respone in cyclosporine-dependent aplastic anemia[J].Blood,1999,93(9):3008-3016.
  • 5Callera F,Garcia AB,Falcao RP.Fas-mediated apoptosis with normal expression of bcl-2 and p53 in lymphocytes from aplastic anemia[J].Br J Haematol,1998,100:698.
  • 6Asano Y,Shibata S,Kobyashi S,et al.Effect of intreleukia-10 on the hematopoietic progenitor cells from patients with patients with aplastic anemia[J].Stem Cell,1999,17:147.
  • 7Bacigalupo A,Brand R,Oneto R,et al.Treatment of acquired severe aplastic anemia:bone marrow transplantation compared with immunosuppressive therapy-The European group for blood and marrow transplantation experience[J].Semin Hematol,2000,37(1):69-80.
  • 8Goldenberg NA,Graham DK,Liang X.Successful treatment of severe aplastic anemia in children using standardized immunosuppressive therapy with antithymocyte globulin and cyclosporine A[J].Pediatr Blood Cancer,2004,43(7):718-722.
  • 9Brodsky RA,Chen AR,Brodsky I,et al.High-dose cyclophosphamide as salvage therapy for severe aplastic anemia[J].Exp Hematol,2004,32(5):435-440.
  • 10Frickhofen N,Heimpel H,Kaltwasser JP,et al.Antithymocyte globulin with or without cyclosporine A:11-year follow-up of a randomized trial comparing treatments of aplastic anemia[J].Blood,2003,101:1236-1242.

共引文献5

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二级引证文献3

南京医科大学学报（自然科学版）
2009年 第3期

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