药物治疗对清创术后血清C─反应蛋白变化的观察

Effects of Pharmaceutical Therapy on the Changes of post-debridement Serum C-Reactive Protein

目的观察药物治疗对清创术后血清Ｃ──反应蛋白的变化。方法清创术后患者分为２组：Ａ组采用中药一盘珠汤加青霉素钠盐治疗，Ｂ组单用青霉素钠盐治疗，对比两组的治疗效果。在治疗过程中观察体温、白细胞计数和血清Ｃ──反应蛋白的变化。结果治疗３天、５天和７天后，两组的血清Ｃ──反应蛋白均有不同程度的下降，但Ａ组显著低于Ｂ组；而体温、白细胞计数在术后７天，两组才显示差异。两组术后感染发生率分别为８．３％和２０％。结论清创术后患者在应用抗生素的同时加用中药治疗，可降低感染的发生率。血清Ｃ──反应蛋白的监测有助于早期发现感染及其某些药物疗效的观察。

Aim To observe the effects of pharmaceutical therapy on the post-debridement serum Creactive protein.' Methods. There were 2 groups for treatment: group A treated with Chinese traditional medicine, Yi Pan Zhu decoction plus sodium penicillin, and group B only with sodium penicillin. For the comparison of the therapeutic effects between them, the body temperature, WBC count and serum C-reac- tive protein, in the course of treatment, had been examined to find out the difference between these two groups. Results 3, 5 and 7 days after the treatment, the contents of serum C-reactive protein were decreased to various degree in these two groups, and the content of serum C-reactive protein in group A was significantly lower than that in group B. But the differences of temperature and WBC count between these two groups were appeared 7 days after operation. The postoperative infection rate was 8. 3% in group A and 20% in group B. Conclusion The application of the antibiotics plus traditional Chinese medicine can decrease the postoperative infection rate in the post-debridement patients. The change of serum C-reactive protein is beneficial to early finding of infection and observation of therapeutic effect of some drugs.