青蒿素与磺胺类药物合并用药抗疟作用的研究

Study on Antimalarial Activity of Qinghaosu in Combination with Sulfa Drugs

观察青蒿素（ＱＨＳ）和磺胺类药物合并用药对伯氏鼠疟原虫抗复燃作用。结果表明，在ＱＨＳ为１００～４００ｍｇ／ｋｇ时，ＱＨＳ与磺胺嘧啶（Ｓｕｌｆａｄｉａｚｉｎｅ，ＳＤ）及周效磺胺（Ｓｕｌｆａｄｏｘｉｎｅ，ＳＤＭ′）合并用药能明显延缓或完全消除鼠疟原虫的复燃现象。虽然不同的磺胺药的抗疟效价并不相同。

The antirecrudescent effects of Qinghaosu(QHS)in combination with sulfa drugs were studied in mice infected with Plasmodium berghei.Results showed that the combinations of QHS 100～400 mg/kg with Sulfadiazine(SD) or Sulfadoxine(SDM′) could eliminate recrudescence of Plasmodium berghei or postpone the interval between parasitemia clearance and its recrudescence. When QHS dose was increased up to 400 mg/kg, all the combinations with different sulfa drugs could delay reappearance of the parasites in the blood, although antimalarial potency of the sulfa drugs varied. \ \