单核细胞趋化因子-1、高敏C反应蛋白与2型糖尿病大血管病变关系的研究

Study on relationship between monocyte chemoattractantprotein - 1, high - sensitivity C - reactive protein and macrovascular complications in type 2 diabetes mellitus

目的探讨2型糖尿病患者血清单核细胞趋化因子-1（MCP—1）、高敏C反应蛋白（hsCRP）水平的变化及其与大血管病变的关系。方法选择2型糖尿病患者62例，其中2型糖尿病并发大血管病变组（A组）32例，无大血管病变组（B组）30例，另选择30例健康者为对照组（C组）。分别测定3组患者血清中MCP—1、hsCRP水平，并进行相关性分析。结果A组和B组血清MCP-1、hsCRP水平均高于C组，差异有统计学意义（P〈0．01）；A组明显高于B组，差异有统计学意义（P〈0．01）。相关分析：血清MCP—1与hsCRP正相关（r=0．748，P〈0．05）。结论血清hsCRP、MCP-1水平的检测对预测2型糖尿病大血管病变的发生发展有重要的临床意义。

Objecive To explore the changes of serum monocyte chemoattractant protein -1 （ MCP - 1 ）, hypersensitivity C - reactive protein （ hsC - RP） and the relations of them to vascular complications in patients with type 2 diabetes mellitus （T2DM）. Methods Sixty - two caseswith type 2 diabetes were divided into two groups：group A （n ： 32） was with macrovascular complication and group B （n = 30） without. Thirty healthy subjectswere selected as control group（ group C）. The serum MCP- 1, hsC - RP was determined and correlate analyze in the three groups were also done. Results The level of MCP - 1 ,hsC - RP in group A and B was significantly higher than that in group C（ P 〈0.01 ）, while it was higher in diabetic patients with macrovascular complications than that in diabetic patients without macrovascular complications（ P 〈 0. 01 ）. Correlation analysisindicated that there existed positive correlations between MCP - 1 and hsC - RP （ r = 0. 748, P 〈 0.05 ）. Conclusions The hsC - RP, MCP - 1 may play an important role in the pathogenesis of diabetes mellitus and its macrovascular complications and can be applied to predict the development of macrovascular diseases as an early predicator.