探讨血浆巨噬细胞移动抑制因子与冠心病的相关性

Plasma macrophage migration inhibitory factor correlated with coronary heart disease

目的观察冠心病患者血浆巨噬细胞移动抑制因子（MIF）水平，并探讨MIF与冠心病的关系。方法68例冠心病患者分为急性心肌梗死（AMI）组14例，不稳定型心绞痛（UAP）组37例，稳定型心绞痛（SAP）组17例，20例冠状动脉造影结果正常者为对照组。采用酶联免疫吸附法（ELISA）测定血浆MIF水平。结果血浆MIF在AMI和UAP组中高于SAP组和对照组，差异有统计学意义（P〈0．05），在SAP组与对照组之间差异无统计学意义（P〉0．05）；血浆MIF在单支、双支、三支病变组中均高于对照组（P〈0．05），但在单支、双支与三支病变组之间差异均无统计学意义（P〉0．05）。结论MIF可作为预测斑块稳定性的标志物，为冠心病危险分层及采取积极干预措施提供依据，但不能反映冠状动脉狭窄程度及范围。

Objective To test plasma macrophage migration inhibitory factor of coronary heart disease（CHD） patients and evaluate whether plasma macrophage migration inhibitory factor were associated with CHD. Methods Sixty -eight patients with CHD were divided into the acute myocardial infarction （AMI） group （ n = 14 ）, the unstable angina pectoris （UAP） group （ n = 37 ） and the stable angina pectoris （SAP） （n = 17） ,20 normal subjests without CHD diagnosed by CAG served as the control group. The plasma level of MIF measured by enzyme linked immune sorbent assay （ELISA）. Results The plasma level of MIF were higher in AMI and UAP group that in SAP group and control group （ P 〈 0.05 ）, The mean level of MIF in SAP group was not significant different, compared with that in control （ P 〉 0.05 ） ; The mean level of s MIF in single,double and three vessel lesion group were higher than that in control group （ P 〈 0. 05） ,but the plasma level of MIF among single, double and three were not significant differents （P 〉 0. 05）. Conclusions MIF may act as one of vulnerable plaques,we can take active to stabilize vulnerable plaques and decrease the occurrence of cardiac events, but may not reflect the severity of artery stenosis.