甲状腺机能亢进症糖耐量改变的探讨

A study on the changes of glucose tolerance in hyperthyroidism

对132例甲状腺机能亢进症病人进行分析，结果表明：①糖耐量减低占15．2％，糖耐量试验曲线呈糖尿病样改变者占19．7％。治疗后糖耐量减低组70％病人于2周左右血糖恢复正常，糖耐量曲线呈糖尿病样组病人血糖恢复较慢，治疗1个月左右仅11．5％血糖恢复正常，57．7％仍呈糖耐量低减状态，30．8％仍为糖尿病样改变。②胰岛素释放试验示糖耐量曲线呈糖尿病样组病人释放高峰后延，胰岛素敏感性也低于正常对照组。提示糖耐量曲线呈糖尿病样组病人的糖耐量改变，可能存在胰岛β细胞胰岛素分泌反应异常和外周组织胰岛素抵抗。

The results of 75g oral glucose tolerance tests (OGTT) in 132 cases of hyperthyroidism were analyzed. ① 15. 2% of the patients showed impaired glucose tolerance (IGT), 19. 7% of the patients. Presented glucose tolerance compatible with diabetes(GTCD). After antithyroid treatment, 70% of the IGT group became normal in a period of mean 14. 6±4. 6 days, but only 11. 5% of the GTCD group became normal after a period of mean 31. 4 ± 7. 2 days of treatment,while 57. 7 % of the patients were in IGT state and the rest (30. 8% ) remained unchanged.②the peaks of insulin release in the GTCD group were delayed and insulin sensitivities were lower than in the normal. These findings suggested that there might be abnormal iresponse of β-cell insulin secretion and peripheral tissue insulin resistance in hyperthyroidism with diabetic glucose tolerance.