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温血心脏停搏液持续灌注对长时间停搏心肌的保护作用

Experimental Studies of Effect of Continuous Warm Blood Cardioplegia on Myocardial Protection for Long Period Arrested Hearts
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摘要 目的利用猫体外循环模型对比观察间断冷血、持续冷血及持续温血心脏停搏液灌注对长时间停搏心肌的保护作用。方法健康猫24只,随机分成4组:Ⅰ组为正常对照组,取正常猫心测定有关指标做为正常对照;Ⅱ~Ⅳ组为心脏停搏组,停搏时间3小时,用不同心肌保护方法保护心肌。结果心脏停搏3小时后心肌线粒体呼吸功能、氧化磷酸化能力及心肌三磷酸腺苷(ATP)含量在间断冷血组明显下降,持续冷血组呈轻度下降,持续温血组保持正常。结论持续灌注温血停搏液技术可使心脏在停搏期间有充足的血液供应,是一种理想的心肌保护方法,特别适用于需长时间停搏和高危病例。 Objective Using the cat cardiopulmonary bypass, the present study was designed to ascertain whether continuous warm blood cardioplegia can prevent arrested heart from myocardial ischemia. Methods Twenty four cats weighing 3-3.5 kg were divided randonly into 4 groups. Hearts in group Ⅰ were not subjected to ischemic arrest, hearts in group Ⅱ with intermittent cold blood cardioplegia, hearts in group Ⅲ with continuous cold blood cardioplegia, hearts in group Ⅳ with continuous warm blood cardioplegia. Results After 180 min of cardiac arrest, mitochondrial function and myocardial ATP content were slightly depressed in group Ⅲ with continuous cold blood cardioplegia, significantly depressed in group Ⅱ with intermittent cold blood cardioplegia, and kept normal in group Ⅳ with continuous warm blood cardioplegia. Conclusion Our data indicate that the method of continuous warm blood cardioplegia is safe and effective and represents a new conceptual approach to maintaining excellent myocardial preservation during a long period cardiac arrest.
出处 《中国胸心血管外科临床杂志》 CAS 1998年第2期101-103,共3页 Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词 线粒体 心肌能量 心肌缺血 体外循环 Mitochondria Myocardial energy Myocardial ischemia Extracorporeal circulation Cats
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