胶体磨制备冰片-β环糊精包合物工艺研究

Reparation of Borneol-β-Cyclodextrin Inclusion Compound Process by Colloid Mill

目的:研究冰片β-环糊精胶体磨包合冰片的最佳工艺。方法:用正交试验设计法,以冰片包合率和包合物收得率为考察指标,研究物料比例、碾磨时间及加水量对使用胶体磨制备冰片β-环糊精包合物效果的影响。结果:优化工艺为:冰片与β-环糊精比例为1∶8,碾磨时间为45min,加水量为1倍。结论:经实验优选得到的工艺所得冰片包合率和包合物的收得率分别为95.2%和95.9%。

objective ：To study the best technology of borneol-β-cyclodextrin inclusion compound process. Method：by the method of or- thogonal experiment, with the rate and yield of borneol-β-cyclodextrin as investigation index;to study and research the rate of materials, the time of grinding,the amount of imbitition which effect the result of borneol-β-Cyclodextrin inclusion compound process by colloid mill. Result：the optimize of technology：the rate of materials is 1：8 ;the time of grinding is 45 min;the amount of imbitition is 1. Conclusion：by optimizeing of technology, the rate and yield of Borneol-β-Cyclodextrin are 95.2% and 95.9%.