代谢综合征与阻塞型睡眠呼吸暂停综合征的相关性分析

Study on the correlation between metabolism syndrome and obstructive sleep apnea syndrome

目的初步探讨代谢综合征（MS）与阻塞型睡眠呼吸暂停综合征（OSAS）的相关性。方法测定并分析82例OSAS患者中43例MS患者（MS组）和39例非MS患者（非MS组）的睡眠呼吸监测指标、MS的组成成分等。结果（1）MS组的腰围（WC）、体重指数、收缩压（SBP）、InTG、InFBG均高于非MS组（P〈0．05或〈0．01），高密度脂蛋白胆固醇（HDL-C）低于非MS组（P〈0．05）。（2）MS组的睡眠呼吸暂停低通气指数（AHI）高于非MS组，最低脉氧饱和度（LSpO2）低于非MS组汾别为（43．95±19．18）次／h比（10．58±3．52）次／h、0．67±0．15比0．82±0．07，P〈0．01]。（3）3个代谢异常组分时，AHI高于0—2个代谢异常组分、LSpO2低于0—2个代谢异常组分（P〈0．01）；代谢异常组分数进一步增加到4-5个时，AHI进一步增高、LSpO2进一步降低（P〈0．05）。（4）AHI与InFBG、WC、SBP呈正相关（P〈0．01），与HDL-C呈负相关（P〈0．01）。（5）LSpO2与InFBG、WC、SBP呈负相关（P〈0．01），与HDL-C呈正相关（P〈0．05）。结论MS和OSAS关系密切。

Objective To explore the correlation between metabolism syndrome （MS） and obstructive sleep apnea syndrome （OSAS）. Methods Forty-three MS subjects （MS group） and 39 non-MS subjects （ non-MS group ） were involved in this study. Polysomnography parameters such as apnea hypopnea index （AHI）, the lowest pulse oxygen saturation （LSpO2）, MS-associated parameters such as lipid, fasting blood glucose （FBG）, blood pressure, and some body indexes such as body mass index （BMI）and waist circumference（WC ）were measured in all cases. Results （ 1 ） WC, BMI, SBP, InTG and lnFBG were higher in MS group than those in non-MS group （P 〈 0.05 or 〈 0.01 ）, HDL-C was lower in MS group than that in non-MS group （P 〈 0.05 ）. （2）AHI in MS group was significantly higher than that in non-MS group,while KSpO2 in MS group was significantly lower than that in non-MS group [ （43.95 ± 19.18 ） times/h vs （ 10.58 ± 3.52 ） times/h, 0.67 ± 0. 15 vs 0.82 ± 0.07, respectively, P 〈 0.01 ） ]. （ 3 ）AHI increased and LSpO2 decreased obviously in 3 kinds of abnormal metabolic ingredients group than that in 0-2 kinds of abnormal metabolic ingredients group （P〈 0.01 ）. Moreover, AHI further increased and ISpO2 decreased obviously in 4-5 kinds of abnormal metabohc ingredients group than that in 3 kinds of abnormal metabolic ingredients group （P 〈 0.05）.（4） AHI was positively correlated with InFBG, WC, SBP and negatively correlated with HDL-C （P 〈 0.01 ）. （5） LSpO2 was negatively correlated with lnFBG, WC, SBP （P 〈 0.01 ） and positively correlated with HDL-C（P〈 0.05）. Conclusion There is close relationship between MS and OSAS.