摘要
目的探讨子宫颈鳞癌组织和正常宫颈组织中KAI1/CD82的表达及其临床意义。方法应用免疫组化SABC法,检测13例正常子宫颈上皮和54例子宫颈癌组织中KAI1/CD82的表达,并进行比较分析。结果13例正常子宫颈上皮中KAI1/CD82的表达均为阳性(13/13);子宫颈癌组织中KAI1/CD82的表达降低(28/54,P<0.01);子宫颈癌组织KAI1/CD82的表达与淋巴结转移显著相关(P<0.01)。结论KAI1/CD82在子宫颈鳞癌中表达下调,与子宫颈癌淋巴结转移有关。
Objective To investigate the clinical significance in KAI1/CD82 expressions in cervical squamous cancer tissues and normal cervical tissues. Methods The expression of KAI1/CD82 were assayed by SABC immunohistochemieal methods in 54 eases of cervidal cancer tissues and 13 cases of normal cervical tissues. Results Positive expression of KAI1/CD82 was detected in 13 normal cervical tissue （ 13/13 ）. KAI1/CD82 expression is down - regulated in cervical carcinoma（ 28/54, P 〈 0.01 ）. The expression of KAI1/CD82 in cervical cancer tissues signiticantly correlate with lymph node metastasis（ P 〈 0.01 ）. Conclusion KAI1/CD82expression is down - regulated in cervical carcinoma, and is to correlate with lymph node metastasis.
出处
《临床和实验医学杂志》
2009年第3期4-5,共2页
Journal of Clinical and Experimental Medicine
基金
江苏省淮安市科研基金资助项目(HAS06036)
