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肝细胞癌克隆起源研究进展 被引量:1

Clonal origin of hepatocellular carcinoma:recent progress
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摘要 多结节和复发性肝细胞癌可分为肝内转移和多中心发生两种,其克隆起源方式与临床诊治密切相关,根据其克隆起源方式设计合理的治疗方案是肝脏外科亟待解决的新问题。本文就近来国内外关于肝癌多中心发生的临床病理学特点、分子诊断及临床意义作一综述。 Multinolular and intrahepatic recurrent HCC can originate from intrahepatic metastasis and multiple origins, and their colnal origin is closely related to the clinical diagnosis and treatment. To designate suitable therapeutic strategies according to their colnal origin is a new challenge needs to be tackled urgently. This paper reviews recent progress in the clinicopathological features, molecular diagnosis and clinical outcomes of multiple origin HCC.
作者 王斌 丛文铭
出处 《第二军医大学学报》 CAS CSCD 北大核心 2009年第3期309-312,共4页 Academic Journal of Second Military Medical University
基金 国家自然科学基金(30872506)~~
关键词 肝肿瘤 肝细胞癌 肿瘤形成过程 多中心发生 肝内转移 liver neoplasms hepatocellular carcinoma neoplastic processes multicentric occurrence intrahepatic metastasis
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  • 1Shimada M, Hamatsu T, Yamashita Y, Rikimaru T, Taguchi K, Utsunomiya T, et al. Characteristics of multicentric hepatocellular carcinomas: comparison with intrahepatic metastasis [J]. World J Surg,2001,25:991-995.
  • 2Liver Cancer Study Group of Japan. The general rules for the clinical and pathological study of primary liver cancer[M]. 4th edn. Tokyo: Kanahara, 2000 : 32-33.
  • 3Utsunomiya I. Pathological study on multicentric occurrence of hepatocellular carcinoma [J]. Kurume Med J, 2005,52 : 133- 138.
  • 4Wang J,Li Q,Sun Y,Zheng H,Cui Y,Li H,et al. Clinicopathologic features between muhicentric occurence and intrahepatic metastasis of multiple hepatocellular carcinomas related to HBV[J]. Surg Oncol, 2009,18 : 25-30.
  • 5Oikawa T, Ojima H, Yamasaki S, Takayama T, Hirohashi S, Sakamoto M. Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules[J]. J Hepatol, 2005,42 : 225-229.
  • 6Portolani N, Coniglio A, Ghidoni S, Giovanelli M, Benetti A, Tiberio G A, et al. Early and late recurrence after liver resection for hepatocellular carcinoma: prognostic and therapeutic implications[J]. Ann Surg, 2006,243 : 229-235.
  • 7Arii S, Yamaoka Y, Futagawa S, Inoue K, Kobayashi K, Kojiro M, et al. Results of surgical and nonsurgical treatment for small sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan[J]. Hepatology, 2000,32 : 1224-1229.
  • 8Toyoda H, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, et al. Simultaneous muhicentrie occurrence of early hepatocellular carcinoma in a patient with persistent alpha-fetoprotein elevation[J]. Hepatol Res, 2007,37 : 988-989.
  • 9Shirabe K, Wakiyama S, Gion T, Motomura K, Koyanagi T, Sakamoto S, et al. Clinicopathological risk factors linked to recurrence pattern after curative hepatic resection for hepatocellular carcinoma-results of 152 resected cases[J]. Hepatogastroenterology, 2007,54 : 2084-2087.
  • 10Yoneyama H, Hara T, Kato Y, Yamori T, Matsuura E T, Koike K. Nucleotide sequence variation is frequent in the mitochondrial DNA displacement loop region of individual human tumor cells[J]. Mol Cancer Res, 2005,3: 14-20.

二级参考文献13

  • 1Nishikawa M, Nishiguchi S, Shiomi S, Tamori A, Koh N, Takeda T, Kubo S, Hirohashi K, Kinoshita H, Sato E, Inoue M. Somatic mutation of mitochondrial DNA in carcerous and noncarcerous liver tissue in individuals with hepatocellular carcinoma. Cancer Research, 2001, 61(5):1843~1845.
  • 2Yamamoto H,Tanaka M,Katayama M,Obayashi T,Nimura Y,Ozawa T.Significant existence of deleted mitochondrial DNA in cirrhotic liver surrounding hepatic tumor.Biochem Biophys Res Commun,1992,182:913~920.
  • 3Kotake K,Nonami T,Kurokawa T,Nakao A,Murakami T,Shimomura Y.Human livers with cirrhosis and hepatocellular carcinoma have less mitochondrial DNA deletion than normal human livers.Life Sci,1999,64(19):1785~1791.
  • 4Richter C,Park J W,Ames B N. Normal oxidative damage to mitochondrial and muclear DNAis extensive.Proc Natl Acad Sci USA, 1988, 85 (17): 6465~6477.
  • 5Cadet J,Berger M,Douki T,Morin B,Raoul S,Ravanat J L,Spinelli S.Oxidative damage to DNA: formation, measurement,and biological significance.Rev Physiol Biochem Pharmacol, 1997,131:1~87.
  • 6Richter C.Oxidative damage to mitochondrial DNA and its relationship to ageing.Int J Biochem Cell Biol, 1995,27(7):647~653. Review.
  • 7Nomoto S, Yamashita K, Koshikawa K, Nakao A, Sidransky D.Mitochondrial D-Loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma.Clin Cancer Res, 2002,8(2):481~487.
  • 8Gille J J,Joenje H.Cell culture models for oxidative stress:superoxide and hydrogen peroxide versus normolaric hyperoxia.Mutat Res, 1992, 275:405~414.
  • 9Zhang Y,Marcillat O,Giulivi C,Ernster L,Davies K J.The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J Biol Chem,1990,265:16330~16336.
  • 10Allen R G,Balin A K.Oxidative influnce on development and differentiation:An overview of a free radical theory of development.Free Radical Biology & Medicine,1989,6(6):631~661.

共引文献12

同被引文献15

  • 1叶文飞,王殿昌.多原发癌[J].中国癌症杂志,1996,6(2):136-138. 被引量:1
  • 2黄灿,樊嘉,邱双健,周俭,吴志全,汤钊猷.原发性肝癌伴肝外恶性肿瘤32例临床分析[J].中国实用外科杂志,2005,25(12):748-749. 被引量:4
  • 3Hayat MJ,Howlader N,Reichman ME,et al.Cancer statistics,trends,and multiple primary cancer analyses from the Surveillance,Epidemiology,and End Results(SEER)Program[J].Oncologist,2007,12(1):20-37.
  • 4Parkin DM.Bray F,Ferlay J,et al.Global cancer statistics,2002[J].CA Cancer J Clin,2005,55(2):74-108.
  • 5Ferná ndez-Ruiz M,Guerra-Vales JM,Castelb ó n-Fernández FJ.et al.Multiple primary malignancies in Spanish patients with hepatocellular carcinoma:analysis of a hospital-based tumor registry[J].J Gastroenterol Hepatol,2009,24(8):1424-1430.
  • 6吴秉铨,刘彦仿.免疫组织化学病理论断[M].北京:北京科学技术出版社,2007,85-475.
  • 7Wang LL,Lurie F,Takanishi DM Jr.Other primary neoplasms in patients with hepawcellular cancer:prognostic implications?[J].Hawaii Med J,2007,66(8):204,206-208.
  • 8Bruno G,Andreozzi P,Graf U,et al.Hepatitis C virus:a high risk factor for a second primary malignancy besides hepatoeellular carcinoma.Fact or fiction?[J].Clin Ter,1999,150(6):413-418.
  • 9Koide N,Hanazaki K,Fujimori Y,et al.Synchronous gastric cancer associated with hepatocellular carcinoma:a study of 10 patients[J].Hepatogastroenterology,1999,46(29):3008-3014.
  • 10Nagao Y,Sata M.High incidence of multiple primary carcinomas in HCV-infected patients with oral squamous cell carcinoma[J].Med sci Monit,2009,15(9):CR453-CR459.

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