Ge-132的糖苷衍生物的合成及抗肿瘤活性

The Synthesis and Antitumor Activity of Glucopyranosyl Derivatives of Cerboxyletnylgermanlum Sesquioxide(Ge-132)

在三乙胺存在下，溴乙酰葡萄糖与Ge－132反应，得到了Ge－132的葡萄糖苷衍生物（包括2，4－二－O－乙酰基－1，3，6－三－O－羧乙基锗基－β－D－葡萄糖苷，Ⅰ及Ⅱ），并对其进行了结构、物理化学性质及抑制肿瘤活性等方面的实验。

Glucopyranosyl organogermanium compounds(such as 2. 4-di-o-acetyl-1. 3. 6-tri-o-carboxyletnylgermanyl-β-D-glucopyranose [Ⅰ] and [Ⅱ] were obtained for the reaction of glucopyranosyl bromide tetracetate with Ge-132 under the presence of Net3 at the room temperature for 2~3 h. The structure, properties and bioactivity were studied. The (results of) antitumor activity experiment showed that when given ip., a maximum inhloltion of 19. 62% for the growth of EEAC of the mice was obtained for the compound Ⅰ.