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辉瑞终止阿西替尼对胰癌、前列腺癌Ⅲ期临床研究 被引量:1

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摘要 阿西替尼(axitinib)是辉瑞公司抗肿瘤领域重要的在研药物,是一种口服的选择性血管内皮生长因子受体抑制剂。包括VEGF1受体,VECF2受体和VECF3受体。
作者 姚瑜 马燕
出处 《国外医药(抗生素分册)》 CAS 2009年第2期95-96,共2页 World Notes on Antibiotics
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  • 1Herrmann E, Bierer S, Wulfing C metastatic renal cell carcinoma[ J] - 309. Update on systemic therapies of World J Urol, 2010, 28:303.
  • 2Pfizer Labs. Highlights of prescribing information for Inlyta : [ EB/ OL]. http://www, accessdata, fda. gov/drugsatfda_docs/label/ 2012/202324 lbl. pdf,2012 - 12 -30.
  • 3Hu- Lowe DD, Zou HY, Grazzini ML, et al. Nonclinical antian- giogenesis and antitumor activities of axitinib ( AG - 013736 ), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3 [ J ]. Clin Cancer Res, 2008, 14:7272 - 7283.
  • 4Kelly R J, Rixe O. Axitinib - a selective inhibitor of the vascular endothelial growth factor (VEGF) receptor[ J]. Targ Oncol, 2009, 4:297 - 305.
  • 5Wilmes LJ, Pallavicini MG, Fleming LM, et al. AG -013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast - enhanced magnetic resonance imaging [ J ]. Magn Reson Imaging, 2007, 25:319 - 327.
  • 6Center for drug evaluation and research. Drug Inlyta : (axitinib) tablets for oral administration [ EB/OL ]. http ://www. accessdata. fda. gov/drugsatfda _ docs/nda/2012/202324 Origls00OMedR. pdf, 2012 -02 - 14.
  • 7Pithavala YK, Tong W, Mount J, et al. Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers invest [ J ]. In- vest New Drugs, 2012, 30:273 -281.
  • 8Pithavala YK, Tortorici M, Toh M, et al. Effect of fifampin on the pharmacokinetics of Axitinib (AG-013736) in Japanese and Cau- casian healthy volunteers [ J ]. Cancer Chemother Pharmacol, 2010, 65 : 563 - 570.
  • 9Rixe O, Bukowski RM, Michaelson MD, et al. Axitinib treatment in patients with cytokine - refractory metastatic renal - cell cancer: a phase II study[J]. Lancet Oncol, 2007, 8:975 -984.
  • 10Tortoriei MA, Toh M, Rahavendran SV, et al. Influence of mild and moderate hepatic impairment on axitinib pharmacokineties [ J ]. Invest New Drugs ,2011, 29 : 1370 - 1380.

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