辉瑞终止阿西替尼对胰癌、前列腺癌Ⅲ期临床研究
被引量:1
摘要
阿西替尼(axitinib)是辉瑞公司抗肿瘤领域重要的在研药物,是一种口服的选择性血管内皮生长因子受体抑制剂。包括VEGF1受体,VECF2受体和VECF3受体。
出处
《国外医药(抗生素分册)》
CAS
2009年第2期95-96,共2页
World Notes on Antibiotics
同被引文献14
-
1Herrmann E, Bierer S, Wulfing C metastatic renal cell carcinoma[ J] - 309. Update on systemic therapies of World J Urol, 2010, 28:303.
-
2Pfizer Labs. Highlights of prescribing information for Inlyta : [ EB/ OL]. http://www, accessdata, fda. gov/drugsatfda_docs/label/ 2012/202324 lbl. pdf,2012 - 12 -30.
-
3Hu- Lowe DD, Zou HY, Grazzini ML, et al. Nonclinical antian- giogenesis and antitumor activities of axitinib ( AG - 013736 ), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3 [ J ]. Clin Cancer Res, 2008, 14:7272 - 7283.
-
4Kelly R J, Rixe O. Axitinib - a selective inhibitor of the vascular endothelial growth factor (VEGF) receptor[ J]. Targ Oncol, 2009, 4:297 - 305.
-
5Wilmes LJ, Pallavicini MG, Fleming LM, et al. AG -013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast - enhanced magnetic resonance imaging [ J ]. Magn Reson Imaging, 2007, 25:319 - 327.
-
6Center for drug evaluation and research. Drug Inlyta : (axitinib) tablets for oral administration [ EB/OL ]. http ://www. accessdata. fda. gov/drugsatfda _ docs/nda/2012/202324 Origls00OMedR. pdf, 2012 -02 - 14.
-
7Pithavala YK, Tong W, Mount J, et al. Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers invest [ J ]. In- vest New Drugs, 2012, 30:273 -281.
-
8Pithavala YK, Tortorici M, Toh M, et al. Effect of fifampin on the pharmacokinetics of Axitinib (AG-013736) in Japanese and Cau- casian healthy volunteers [ J ]. Cancer Chemother Pharmacol, 2010, 65 : 563 - 570.
-
9Rixe O, Bukowski RM, Michaelson MD, et al. Axitinib treatment in patients with cytokine - refractory metastatic renal - cell cancer: a phase II study[J]. Lancet Oncol, 2007, 8:975 -984.
-
10Tortoriei MA, Toh M, Rahavendran SV, et al. Influence of mild and moderate hepatic impairment on axitinib pharmacokineties [ J ]. Invest New Drugs ,2011, 29 : 1370 - 1380.
二级引证文献7
-
1荣海健,郑军华.肾细胞癌患者生活质量的研究现状[J].外科研究与新技术,2015,4(1):64-67. 被引量:2
-
2王绍钧,王锐,朱冬波.实体瘤靶向药物的研究进展[J].中国药房,2017,28(8):1149-1152. 被引量:5
-
3谢福晨,陈学栋,郭桂军.阿西替尼辅助肾部分切除术治疗转移性肾细胞癌的疗效分析[J].中国现代医学杂志,2018,28(35):116-119. 被引量:4
-
4闫聪聪,李志寒,贺佳,马姝丽,吴光华,张淼,毛宇彬.酪氨酸激酶抑制药GW2974诱导乳腺癌细胞BT474耐药的代谢机制研究[J].中国临床药理学杂志,2019,35(15):1629-1632. 被引量:3
-
5薛文鑫,张藜莉,程吟楚,门鹏,李静,翟所迪.阿昔替尼治疗晚期或转移性肾细胞癌的快速卫生技术评估[J].中国临床药理学杂志,2020,36(8):1002-1006. 被引量:3
-
6尤燕,牟卫伟.抗血管生成药物的研究进展与临床应用[J].食品与药品,2021,23(1):92-96.
-
7杨丽娟,孙一剑,李娟,代秀兰.脉冲染料激光联合局部治疗在鲜红斑痣中的应用进展[J].中国医疗美容,2023,13(2):61-64. 被引量:1
-
1辉瑞肺炎疫苗临床试验大获成功[J].医药前沿,2015,5(11):1-1.
-
2血管内皮生长因子受体抑制剂——Axitinib[J].药学进展,2008,32(4):186-188. 被引量:2
-
3任佚,封宇飞.晚期肾细胞癌治疗药物阿西替尼的药理作用和临床评价[J].中国新药杂志,2013,22(9):998-1001. 被引量:1
-
4古洁若,余步云,汤美安,钱孝贤.阿西米辛治疗风湿性疾病62例临床观察[J].广东医学,1994,15(5):298-300. 被引量:1
-
5国外新批准上市的药物新制剂新剂型(171)[J].中国制药信息,2012,28(4):10-12.
-
6晚期肾细胞癌治疗药物Axitinib获准上市[J].中国执业药师,2012,9(4):9-9.
-
7杨华章,陈亮,陈重,陈红梅,廖晓征,崔炎棠.格列吡嗪控释片治疗伴高胰岛素血症的2型糖尿病[J].广东医学,2005,26(12):1716-1717. 被引量:3
-
8吕康连,孙平,丁振.双氯灭痛直肠给药治疗肝胆胰晚期癌痛[J].中国临床康复,2002,6(14):2114-2115.
-
9辉瑞中国血脂异常与动脉粥样硬化科研基金申报启事[J].中华内科杂志,2011,50(1):58-58.
-
10辉瑞中国血脂异常与动脉粥样硬化科研基金申报启事[J].中华内科杂志,2010,49(12):1042-1042.