摘要
胰岛素抵抗及胰岛b细胞功能进行性衰竭是2型糖尿病重要的发病机制。目前应用最广泛的改善胰岛素敏感性的两种药物即马来酸罗格列酮和盐酸二甲双胍,其复合片剂现已成功上市。本品具有良好的血糖控制、减轻胰岛素抵抗和保护胰岛b细胞功能等作用,可改善脂肪代谢和降低心血管事件危险因子及相关标志物水平等。本文简要综述罗格列酮-二甲双胍复方制剂的疗效及安全性。
Insulin resistance and progressive β-cell dysfunction are considered as the most important factors in the pathogenesy of type 2 diabetes. Rosiglitazone maleate and mefformin hydrocholride are two prescribed medications that used the most commonly for improving insulin sensitivity. Rosiglitazone-metformin （Avandamet） is the compound prepa- ration of mefformin and rosiglitazone which proved to be more beneficial on the control of glycemia, reduction of insulin resistance and protection of β-cell function. In addition, it can improve the lipid metabolism and decrease the risk of car- diovascular events. This paper reviewed the pharmacologic action, clinical effects and safety of rosiglitazone-mefformin.
出处
《世界临床药物》
CAS
2008年第11期656-660,共5页
World Clinical Drug
