低剂量纳洛酮对芬太尼镇痛效应的影响

The influence of low dose naloxone on the analgesic effect of fentanyl

目的观察低剂量纳洛酮(naloxone)对芬太尼(fentanyl)镇痛效应的影响。方法将试验小鼠80只随机分为两组,分别采用扭体法(40只,雌雄各半)和热板法(40只,均为雌性)观察纳洛酮对芬太尼镇痛小鼠热板法痛阈(HPPT)和扭体次数的影响。各组按分层随机设计分为FS组(芬太尼与生理盐水合用)及FN1、FN2和FN3组(芬太尼分别与纳洛酮100、10、1ng/kg合用组)四组。结果与FS组相比,FN2组HPPT在第5min增大(P<0.05);扭体次数FN1和FN2组均显著减少(P<0.05)。结论纳洛酮在一定剂量范围内能够增强芬太尼的镇痛效应。

Objective To observe the influence of low dose naloxone （naloxone） on the analgesic effect of fentanyl （fentanyl）. Methods Analgesic dose given to the mice were divided into FS Group （fentanyl combined with NS Group）, FN1 group, FN2 group and FN3 Group （fentanyl and small dose of naloxone 100, 10, 1 ng/kg combination group） four groups. With hot plate and writhing on the FN was observed in mice hot plate analgesic pain threshold （pain threshold in hot-plate test, HPPT） and writhing number of implications. Results Compared with the FS, FN2 group, HPPT of group FN2 and FN3 HPPT in 5 min increased （P 〈0.05）, writhing number reduction （P 〈0.05）. Conclusion Low dose naloxone can enhance the analgesic effect of fentanyl.