摘要
目的探讨宫颈鳞状细胞癌(SCC)组织蛋白酶活化受体-1(PAR-1)基因mRNA的表达与临床意义。方法采用反转录聚合酶链反应(RT-PCR)检测49例宫颈鳞状细胞癌组织中PAR-1基因mRNA的表达情况。结果不同病理分级的宫颈鳞状细胞癌中PAR-1的表达率:Ⅰ级31.3%,Ⅱ级42.1%,Ⅲ级50%,各组之间比较差异无显著性意义(P>0.05)。PAR-1 mRNA在宫颈鳞状细胞癌中的表达率:Ⅰ期40%,Ⅱ期35%,Ⅲ期42.9%,各组之间比较差异无显著性意义(P>0.05)。PAR-1 mRNA在无淋巴结转移的宫颈鳞状细胞癌中的表达率为28.6%,在有淋巴结转移的宫颈鳞状细胞癌中的表达率为71.4%,差异有显著性意义(P<0.01)。结论PAR-1mRNA表达增高可能参与宫颈鳞状细胞癌的转移和侵袭过程。
Objective To investigate the clinical significance of the differential expression of PAR-1 in cervix squamous cell carcinoma tissue. Methods The mRNA expressions of PAR-1 were evaluated by reverse transcription polymerase chain reaction （RT-PCR） in 49 cervix squamous cell carcinoma cases. Results The expression rate of PAR-1 was 31.3% ,42. 1% and 50% in different pathological grade cervix squamous cell carcinoma; The position rate of PAR-1 mRNA is 40% ,35% and 42. 9% in different clinical stage. The expression rate of PAR-I mRNA in cervix squamous cell carcinoma without lymph node metastasis was 28.6%, lower than that with lymph node metastasis （ 71.4% ） （ P 〈 O. 01 ）. Conclusion The increase of the expression of PAR-1 mRNA may have very important effect on invasion and metastasis of cervix squamous cell carcinoma.
出处
《实用医院临床杂志》
2008年第5期78-79,共2页
Practical Journal of Clinical Medicine
