胆红素对小鼠腹水型肝癌细胞与人肝癌细胞光敏反应的比较

COMPARISON OF PHOTOSENSITIZATION OF BILIRUBIN BETWEEN THE ASCITIC HEPATOMA CELLS AND HUMAN HEPATOMA CELLS

不同浓度（３８，３．８，０．３８，０．０３８μｍｏｌ／Ｌ）的胆红素光敏反应能使腹水型肝癌细胞（ＨｅｐＡ）和人肝癌细胞致死，死亡率随浓度的增加和照光时间的延长而加剧，ＨｅｐＡ细胞死亡率明显高于人肝癌细胞；避光组细胞也有一定的死亡，说明胆红素本身对细胞也有一定的损伤。

Photosensitization of bilirubin(38,3.8,0.38,0.038 μmol/L) increased the mortality of ascitic hepatoma (Hep A) and human hepatona(BEL7402)cells.The cell mortality was dependent on concentration of bilirubin and the illumination time.The mortality of Hep A cells was much higher than of BEL7402 cells.However,even in the dark group tumor cells were killed slightly.It indicated that bilirubin itself had to some extent toxicity to tumor cells as well.