糖尿病终末肾病维持性血液透析患者相关生物因子的探讨

目的 分析糖尿病终末肾病维持性血液透析患者相关生物因子的变化。方法 收集维持性血液透析患者共54例，分为耱尿病终末肾病（26例为A组）与非糖尿病终末肾病组（25例为B组）。测定血清甲状腺素、瘦素、脂联素、胰岛素等指标进行比较分析。结果 糖尿病终末肾病维持性血液透析患者与其他维持性血液透析患者血清瘦素、胰岛素、胰岛素抵抗指数、空腹血糖水平具有差异。而甲状腺素、脂联素、肌酐、尿素氮水平并无明显不同。结论 糖尿病终末肾病血液透析患者高瘦素、高胰岛素血症较其他维持性血液透析患者更为严重，且存在着胰岛素抵抗，临床中应根据维持性血液透析患者不同的病理生理特点做出针对性的治疗。

Objective：To study the related biologic factor changes of diabetic end-stage renal disease patients with Continuous Renal Replacement Therapy. Methods： 54 Continuous hemodialysis patients participated the research,being divided into diabetic end-stage renal disease and non-diabetic end-stage renal disease.The former 2 groups as well as control group comprise the 3 group in our study.Serum thyroxine,leptin, adiponectin, fasting blood glucose,insulin,insulin resistance index,creatinine and urea nitrogen were tested and analyzed.Results：There were obvious difference in serum leptin,insalin,IRI and FBG between diabetic hemodialysis patients and non-diabetic bemodialysis patients while thyroxine, adipolectin, Cr and Bun were not prominent.Conclusion： Diabetic end-stage renal disease hemodialysis patients had more serious high leptin,insulin and insulin resistance than other continuous hemodialysis patients.Targeted therapy should adopt according to different pathophysiological characteristics during clinical courses.