L-脯氨酸/吡啶催化合成肉桂酸

Synthesis of Cinnamic Acid with the Catalysis of L-Proline/Pyridine

以L-脯氨酸/吡啶为催化剂,正己烷做带水剂,用苯甲醛和丙二酸为原料,经Knoenenagel缩合生成肉桂酸.探讨带水剂的种类、原料比(丙二酸与苯甲醛的量比)、催化剂用量和反应时间等对肉桂酸收率的影响.实验结果表明,合成肉桂酸的最合适条件:原料比为1.0∶0.9,L-脯氨酸用量为丙二酸质量的4.0%,反应时间4 h,在此最佳条件下,肉桂酸的收率达到99.0%.

Cinnamic acid was synthesized from benzaldehyde and malonic acid by knoevenagel condensation with the catalysis of L-proline/pyridine in water-carrying agent hexane. The effect of water-carring agents, mole ratio of malonic acid to benzaldehyde, dosage of catalyst and reaction time on the yield of cinamic acid was discussed. The results show that the optimum conditions are： the mole ratio of malonic acid to benzaldehyde 1. 0 ：0. 9, the dosage of proline 4. 0% of the weight of malonic acid and the reaction time 4h, the yield of cinnamic acid is 99.0% under the optimum conditions.