寒痹康汤对实验性关节炎大鼠血清IL-6 NO的影响

Han Bi Kang Tang on experimental arthritis in rats serum IL-6,NO impact

目的:观察寒痹康汤对实验性关节炎大鼠的血清白介素-6(IL-6)、一氧化氮(NO)的影响,探讨寒痹康汤治疗类风湿关节炎的作用机理。方法:采用牛II型胶原蛋白诱导实验性关节炎模型,以甲氨蝶呤作对照,观察大鼠的关节肿胀指数的变化,采用放射免疫法检测各组大鼠血清IL-6、NO水平。结果:寒痹康汤能显著减轻大鼠关节肿胀指数、显著降低大鼠血清IL-6、NO水平。结论:寒痹康汤能下调实验性关节炎大鼠血清IL-6、NO的水平,其作用与甲氨蝶呤相当,是其治疗类风湿关节炎的作用机理之一。

Objective：To observe the impact of the Han Bi Kang Tang on experimental arthritis in rats serum IL -6 （IL -6）, nitric oxide（ NO）, and discuss Mechanism of the Han Bi Kang Tang treatment of rheumatoid arthritis. Methods：bovine type Ⅱ collagen-induced arthritis in experimental models to methotrexate for the control and observation of swelling in the joints of the index changes, the use of radioimmunoassay were detected level in serum IL - 6, NO. Results ： Hart Bi Kang Tang can be significantly reduced joint swelling in rats index, a significant reduction in serum IL - 6, NO level. Conclusion ： Han Bi Kang Tang experimental arthritis can be reduced in serum IL - 6, NO level, and its role is quite methotrexate,is one of the mechanisms in its treatment of rheumatoid arthritis.