精神发育迟滞儿童血中乙酰胆碱质量浓度的研究

Study on the Blood Acetylcholine Levels in Children with Mental Retardation

目的:探讨精神发育迟滞(MR)儿童血中乙酰胆碱(ACh)质量浓度与智商评分之间的关系。方法:对所有受试者采用中国-韦氏儿童智力量表进行智商测定,并用碱性羟胺法进行外周血ACh的检测。结果:MR组血中ACh水平[(53.6±13.8)μg/mL]明显低于正常对照组[(104.9±12.1)μg/mL](P<0.01),且两组ACh水平均与智商评分呈正相关(P<0.01)。结论:MR儿童智能障碍的发生与血中ACh质量浓度降低有关,而其浓度在一定程度上可作为判断MR儿童病情的客观指标。

Objective： To investigate the relationship between blood acetylcholine levels and intellengence qutioent in children with mental retardation（MR）. Methods： The intellengence qutioent of 30 children with MR and 30 healthy children was assessed with C-WISC test. The blood acetylcholine levels were determined by colorimetric method. Results： The mean concentration of blood acetylcholine in the MR group[ （53.6 ± 13.8）μg/mL] was significantly lower than that of the normal control group[（104.9 ± 12.1）μg/mL] （P 〈 0.01）. There was a positive correlation between blood acetylcholine levels and intellengence qutioent（ P 〈 0.01）. Conclusion： The occurrence of intelligence disturbance in children with MR is associated with the decline in blood acetylcholine levels. The blood acetylcholine levels in children with MR may be used as a predictor for the intelligence state.