细菌性脑膜炎与病毒性脑炎血清中TNF值的测定及临床意义

RADIOIMMUNOASSAY OF TUMOR NECROSIS FACTOR (TNF) AND ITS CLINICAL SIGNIFICANCE IN BACTERIAL MENINGITIS AND VIRAL ENCEPHALITIS

采用放射免疫法检测了３４例细菌性脑膜炎，２６例病毒性脑炎患儿急性期、恢复期血清中肿瘤坏死因子（ＴＮＦ）的含量。结果表明：细菌性脑膜炎急性期ＴＮＦ含量与病毒性脑炎急性期和对照组比较，明显增高（Ｐ＜０．００１），恢复期则降至正常，而病毒性脑炎急性期、恢复期同对照组比较无明显变化（Ｐ＞０．０５）。同时发现ＴＮＦ含量与患儿的病情轻重及预后有关，ＴＮＦ水平越高，则病情重，预后差。说明ＴＮＦ含量的检测对鉴别细菌性脑膜炎与病毒性脑炎、判断预后，有一定的意义。

Radioimmunoassay of serum levels of tumor necrosis factor (TNF) in 34 cases of bacterial meningitis,and 26 cases of viral encephalitis was made during acute stage and restoration stage respectively.Results:TNF level of acute bacterial meningitis is significantly higher than that of acute viral encephalitis and the control group (P<0001),and then the level will get normal in restoration stage;whereas the TNF value of viral encephalitis (either in acute or in restoration stage) remains unchanged in comparison with the control group (P<005).We also found that TNF levels are related to the state and prognosis of the illness.The more the contents,the more severe the state and the worse the prognosis.Conclusions:TNF determination is significant in differentiating bacterial meningitis from viral encephalitis,and judging their prognosis.