青岛地区健康成年人尿酸排泄分数正常值的建立及分析

Reference values of fraction excretion of uric acid in healthy adults in Qingdao area

背景：目前国内缺少关于尿酸排泄分数（fraction excretion of uric acid,FEUA）正常值建立及不同性别、年龄间差异的研究。目的：建立青岛地区健康成年人尿酸排泄分数的正常参考值。设计、时间及地点：调查分析,2007-08/2008-08在青岛大学医学院附属医院完成。对象：选择2007-08/2008-08青岛地区连续居住5年以上的20-70岁的健康者581人,其中男279人,女302人。按年龄分为21~30岁61人,男32人,女29人;31~40岁92人,男40人,女52人;41~50岁173人,男82人,女91人;51-60岁169人,男88人,女81人;〉60岁86人,男37人,女49人。方法：用特定Sysmex chemix-180型全自动生化分析仪测定581例健康成年人的空腹血清及12h尿中尿酸、肌酐浓度,计算尿酸排泄分数,用SPSS16.0软件进行统计学处理。主要观察指标：①正常成年人的一般资料及生化指标比较。②血尿酸、尿酸排泄分数性别间比较及尿酸排泄分数的参考值范围。③血尿酸、尿酸排泄分数在不同年龄组间的比较。结果：男性血尿酸高于女性,而尿酸排泄分数低于女性,差异均有显著性意义（P〈0.05）。各年龄组间尿酸排泄分数差异无显著性意义（P〉0.05）。女性尿酸排泄分数参考值范围为4.039%-10.613%,男性为3.447%-9.915%。结论：初步建立了青岛地区健康成年人尿酸排泄分数的正常参考值。应分别建立男女性尿酸排泄分数正常参考值及促尿酸排泄治疗标准,为高尿酸血症防治工作提供参考。

BACKGROUND： The studies regarding reference values of fraction excretion of uric acid （FEUA） is poorly understood. OBJECTIVE： To establish reference values of FEUA in healthy adults in Qingdao area. DESIGN, TIME AND SETTING： The investigation and analysis was performed at the Qingdao Medical College from August 2007 to August 2008. PARTICIPANTS： A total of 581 healthy adults with aged 20 70 years, including 279 male and 302 female stayed in Qingdao more than 5 years were selected from August 2007 to August 2008. The adults were divided into groups according to the ages. There were 61 adults in the group aged 21-30 years （32 male and 29 female）; 92 adults in the group aged 31 40 years （40 male and 52 female）; 173 adults in the group aged 41 50 years （82 male and 91 female）; 169 adults in the group aged 51 60 years （88 male and 81 female）; and 86 adults aged more than 60-year-old （37 male and 49 female）. METHODS： The uric acid and creatinine of fasting blood and 12 h urine taken and tested with Sysmex chemix-180 to calculate FEUA, the results were statistically analyzed by SPSS 16.0 software. MAIN OUTCOME MEASURES： （1）Comparison of general information and biochemical index. （2）Comparison of serum uric acid, FEUA in sexes and reference values of FEUA. （3）Comparison of serum uric acid, FEUA in different age groups. RESULTS： Serum uric acid in male was higher, but FEUA was lower than that of female, there were significant difference between different genders （P〈 0.05）. There was no obvious difference in FEUA between age groups （P〉 0.05）. The normal range of FEUA in female and male was 4.039%-10.613% and 3.447% 9.915%, respectively. CONCLUSION： The reference value of FEUA in healthy adults in Qingdao is preliminarily established. To provide evidence for hyperuricemia control and prevention, it is necessary to establish respective reference values of FEUA and prompting the excretion of uric acid for healthy male and female.