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MicroRNA与小儿肿瘤的研究进展

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摘要 MicroRNAs（miRNAs）是近年来发现的一类长度约20～24nt的内源性非编码小分子RNA，它普遍存在于动植物体内，具有高度进化保守性、时序性、组织特异性及基因簇集现象。miRNA参与基因表达转录后的调节，通过碱基配对的方式与靶mRNAsd 3’端非编码区（3’-UTRs）结合，发挥负性调节的作用。到目前已发现了至少1000余种miRNAs，它们参与调控了至少30％的人类蛋白编码基因。
作者 姚伟 李凯
机构地区 复旦大学附属儿科医院外科
出处 《中华小儿外科杂志》 CSCD 北大核心 2009年第3期183-186,共4页 Chinese Journal of Pediatric Surgery
关键词 MICRORNA 小儿肿瘤 miRNAs 小分子RNA 蛋白编码基因 基因表达 非编码区 负性调节
分类号 R686 [医药卫生—骨科学]
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参考文献34

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共引文献18

中华小儿外科杂志
2009年 第3期

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