沈阳地区乙型肝炎病毒基因型与临床特征相关性的分析

The study on the clinical characteristics and distribution of hepatitis B virus genotype in Shenyang

目的:研究沈阳地区基因型分布特点及肝病严重程度相关性的分析。方法:随机选择280例慢性乙型肝炎患者,检测这些患者病毒基因型。结果:沈阳地区慢性乙型肝炎患者中,乙肝病毒基因型为B、C基因型,未见其它基因型,其中C型为198例(70.7%),B型82例(29.3%)。慢性肝炎患者中C基因型(59.1%)低于B基因型(85.4%)(P<0.05);原发性肝癌患者中C基因型(9.6%)高于B基因型(1.2%)(P<0.05);重型肝炎患者中C基因型(8.6%)高于B基因型(1.2%)(P<0.05);肝炎肝硬化患者中C基因型(22.7%)高于B基因型(12.2%)(P<0.05)。结论:沈阳地区存在基因型为B、C型,其中以C基因型为优势基因型。肝癌、肝硬化和慢性重型肝炎与C基因型相关性较大。

Objective： To determine the distribution of HBV genotypes and possible association with the severity of liver disease. Methods： 280 patients infected with HBV in Shenyang were enrolled and HBV genotype was determined Results： Genotypes B and C were classified in 280 patients with HBV in Shenyang, and did not fund others genotypes. Of the 280 patients, 198 （70.7%） were genotype B and 82 （29. 3% ） were genotype C. Compared with genotype B, genotype C was more commonly found in these patients of Hepato - cellular carcinoma, chronic severe hepatitis and liver cirrhosis （P 〈 0. 05）, Genotype C was more rarely found in these patients of chronic hepatitis B than genotype B （P 〈 0. 05 ） . Conclusion： Only genotype B and C can be found in patients with chronic HBV infection in Shenyang and genotype C was the dominant one. Hepato - cellular carcinoma, chronic severe hepatitis and liver cirrhosis showed relations with genotype C.