丙酸睾丸酮、米非司酮与卡孕栓联合应用终止早、中期妊娠的临床研究

Clinical Study of Induced Abortion with Three or Two Drug Combination Therapy

用丙睾、米非司酮与卡孕栓(PG05)3种药物联合与丙睾和卡孕栓两种药物联合终止妊娠进行对照分析,为扩大其临床应用范围提供依据。结果表明,流产成功率分别为97.14％和94.28％,差异无显著性。但流产时间前者为(3.32±1.57)h,后者为(6.15±2.88)h,差异有非常显著性。卡孕栓用量前者(1.06±0.24)mg,后者(3.03±1.44)mg,差异有非常显著性。副反应发生率前者为48.6％,后者62.9％,差异亦有显著性。结论:丙睾、米非司酮和卡孕栓3种药物联合应用流产效果较优。

To provide a clinical evidence and develop the clinical application,a comparative study on termination of gestation between two groups of medicine users was conducted. The first group used the combination of testosterone propionate,mifepristone and PG05,the second group was given testosterone pro-pionate and PG05 only. The analytical results showed that there were no statistical differences on the abortion rate:97. 14% and 94. 28% .respectively. However,the duration of abortion in the first group was significantly shorter than that in the second group (3. 32± 1. 5)h versus (6. 15±2. 88)h. The dosage of PG05 was decreased in the first group,which is significantly different from the second group, ( 1. 06±0. 24)mg and (3. 03± 1. 44)mg respectively. Moreover, there were statistical differences between the two groups on the incidence of side-effect, 48. 6% in the first group and 62. 9% in the second group. It was concluded that the effectiveness of three drug combination therapy to terminate the gestation was better than that of two drug combination therapy.