血清GPDA测定对肝血管瘤与肝癌鉴别诊断的价值

Diagnostic Value of Serum GPDA Detection in Hepato-hemangioma and Hepatocaccinoma

对127例原发性肝癌患者及96例肝血管瘤患者测定了血清甘氨酰脯氨酸二肽氨基肽酶(GPDA),并以86名健康献血员作为对照。结果表明:原发性肝癌患者的GPDA阳性率为67.7％,而血管瘤患者和健康献血员中均未出现阳性,原发性肝癌与肝血管瘤之间有极显著性差异(P<0.001)。肝血管瘤与正常人之间差异无显著性(P>0.05)。结果还显示AFP阴性肝癌患者的GPDA阳性率达70％,GPDA与AFP无相关性。结果表明血清GPDA测定有助于肝癌与肝血管瘤之间的鉴别诊断。文章对GPDA作为肝癌标志物的诊断价值作了讨论。

In this study,serum glycyl proline dipeptidyl aminopeptidase(GPDA) were detected in 127 patients with primary liver cancer, 96 patients wih hepatd-hemangioma and 86 healthy blood dornor. The results showed:The GPDA positive rate in primary liver cancer patients was 67. 7% .while no GPDA was found in hepato-hemangioma patients and controls. There were significant differences between primary liver cancer and hepato-hemangioma(P<0. 001),and no significant differences between hepato- hemangioma and controls(P>0. 05). It also showed that in AFP-negative hepotocarcinoma,the positive rate of GPDA reached 70%. GPDA had no correlation with AFP. Those data suggested that serum GPDA detection was helpful in differential diagnosis of hepatocarcinoma and hepato-hemangioma. The diagnostic value of GPDA as a hepatocarcinoma marker was discussed.