阿立哌唑与利培酮对首发分裂症患者社会功能影响的对照研究

A comparative study of social function in first-episode schizophrenic patients treated with aripiprazol and risperidone

目的比较阿立哌唑与利培酮对首发分裂症患者社会功能的影响。方法分别以阿立哌唑与利培酮维持治疗首发分裂症患者半年,用阳性症状和阴性症状量表(PANSS)、不良反应量表(TESS)、社会功能缺陷量表(SDSS)在治疗前后评定。结果半年后服用阿立哌唑的患者在职业工作、社会退缩、对外界的兴趣方面优于服用利培酮患者,其余无明显差异。结论阿立哌唑、利培酮在维持治疗分裂症患者时,都能显著改善其社会功能。但阿立哌唑在某些方面优于利培酮。

Aim To compare the social function in first-episode schizophrenia patients treated with aripiprazol and risperidone. Methods Recovered patients with first-episode schizophrenia who were treated with aripiprazol and risperidone were followed for half a year. The patients were evaluated with the positive and negative symptom scale（ PANSS）, the treatment emergent symptom scale （TESS）and the social disability screening scale （SDSS）. Results Social functions of the patients were significantly improved in both aripiprazol and risperidone group, but more better in aripiprazol group for some items including profession and job, social withdrawal, interest and care of other things. Conclusion Aripiprazol has similar efficacy as risperidone in improving social function of the patients with schizophrenia, but much better in some aspects than risperidone.