代谢组学在中药方剂整体药效作用及机制研究中的应用与展望

Prospective Consideration on Metabonomic Approach to the Study of Holistic Efficacies and Involved Mechanisms of Traditional Chinese Medicines

建立符合中药方剂自身特点的整体药效评价体系是中药现代化研究的重要科学任务之一,近年来,随着代谢组学科学技术的发展为中药方剂整体药效评价与多靶点作用机制研究提供了崭新的和强有力的技术手段。本论文围绕代谢组学研究技术在中医证动物模型评价、"方证对应"研究、中药整体药效作用评价及作用机制研究等方面的研究现状进行了扼要评析,提出和讨论了代谢组学研究结果的定量表征,多组分多靶点中药与单成分、单靶点化学药物药效作用的代谢组学比较研究,药物代谢动力学与代谢组学整合研究在中药药效物质基础及整体药效作用评价与作用机制研究中重要作用意义。

The establishment of holistic pharmacological efficacies evaluating methods and systems that are consistent with the intrinsic characteristics of traditional Chinese medicines is one of the most important scientific tasks for the modernization of traditional Chinese medicines. Recently, the development and incorporation of metabonomics approach to this field has proved to be a novel and powerful tool for evaluating the holistic efficacies and underlying mechanisms of traditional Chinese medicines. This review contributes a brief summary and comment on the recent progress of metabonomics approach to the study of syndrome animal models, the relationship between syndrome and its corresponding prescription, and the holistic efficacies and involved mechanisms of traditional Chinese medicines. In addition, the current limitations and future prospect of incorporating metabonomic approach into this field, including the quantitative evaluation of metabonomic results, the efficacy-based metabonomic comparison of multi-component multi-target herbal medicines with one-component one-target drugs, and the integrative pharmacokinetics and metabonomics approach to disclosing the mystery of herbal medicines, have been discussed.