肝硬化患者血浆凝血酶原时间和血清肝纤维化指标与Child-Pugh分级的关系

Relationship of Child-Pugh class with plasma prothrombin time and serum liver fibrosis indexes in patients with cirrhosis

目的探讨肝硬化患者血浆凝血酶原时间(PT)、血清肝纤维化指标(PC-Ⅲ、Ⅳ-C、LN、HA)与Child-Pugh肝功能分级的关系。方法按Child-Pugh分级标准将100例肝硬化患者分为A、B、C三级组,测定血浆PT、血清肝纤维化4项指标(PC-Ⅲ、Ⅳ-C、LN、HA)水平。结果A、B、C三级组血浆PT、血清肝纤维化标志物水平随Child-Pugh积分增加而呈上升趋势,三组比较均有显著性差异(P<0.05),血浆PT、血清肝纤维化指标与Child-Pugh分级之间均存在显著正相关性(r=0.359～0.604,P<0.05)。结论联合检测肝硬化患者血浆PT和血清肝纤维化4项指标对指导肝功能Child-Pugh分级具有很好的参考价值,是较理想的实验室诊断肝硬化的指标。

Objective To investigate the relationship of Child-Pugh class with plasma prothrombin time（PT） and serum liver fibrosis indexes in patients with cirrhosis. Methods 100 patients with cirrhosis of liver were divided into stage A, B and C according to Child-Pugh staging. The plasma PT and serum liver fibrosis indexes were measured. Results Plasma PT and serum PC-m ,IV-C,LN and HA level with Child-Pugh score increased and raised,A,B and C grade compared the difference was significant （P〈0.05）. The plasma PT and serum liver fibrosis indexes with the Child-Pugh class have relevance （r=0.359- 0.604,P〈0.05）. Conclusion Measuring the plasma PT and serum liver fibrosis indexes（PC-HI ,IV-C,LN,HA）have an important reference value for guiding Child-Pugh class and are better indicators of laboratory diagnosis in patients with cirrhosis.