河南省永城市疟疾休止期治疗措施的效果评价

Evaluation of therapeutic measures of radical treatment for malaria in pre-transmission season in Yongcheng,Henan,China in 2007

目的评价永城市对不同对象实施不同休止期治疗(简称休治)的效果,为制定疟疾防治对策提供依据。方法选择永城市马桥、李寨和裴桥乡为试点,以行政村为单位根据2006年发病率采取不同的休治方法,发病率≥1%的3个行政村实施全民休治,确定全体常住人口为休治对象;发病率<1%的1个行政村实施病家四邻服药,确定疟史患者、患者家属及其四周邻居为休治对象。确定的休治对象在春季疟疾休止期均给予氯喹/伯喹8d8次服药治疗。收集当年疟疾发病个案调查表、疫情报表和统计表,分析比较疟疾发病情况。结果全民休治村2007年疟疾发病率为0.7%(42/5618),较上年2.3%的发病率下降69.6%,差异有统计学意义(χ2=44.947,P<0.001);实施病家四邻服药村发病率0.4%(8/1955),较上年0.9%的发病率下降55.6%,但差异无统计学意义(χ2=3.261,P=0.071)。10月份以前全民休治行政村月累计疟疾发病率与病家四邻服药村比较差异无统计学意义(χ2=0.501,P=0.479),两组群全年发病率差异也无统计学意义(χ2=2.532,P=0.112)。结论对疟疾发病率≥1%的行政村实施全民休治可扭转疫情上升势头,对发病率<1%的行政村实施病家四邻服药可遏制疫情上升势头。

Objective To evaluate different radical treatment methods for malaria during pre-transmission season in different target people in Yongcheng County, and provide data for malaria control. Methods Maqiao, Lizhai and Peiqiao township in Yongcheng County were selected as trails in this study. According to malaria incidence of village in 2006, 3 villages with malaria incidence of over 1% were given all-people the radical treatment measures, which all stationary pop- ulation were regarded as target. One administration village with malaria incidence of less 1% were given patients-and-relative radical treatment, which malaria patients, his family and neighbour were defined target. All target population were given treatment of Chloroquine and Primaquine for 8 days. Data on malaria epidemic situation, case report, information and statistical table related to observed village were collected and analyzed. Results In 2007, malaria incidence was 0.7%（42/5618） in the villages with all-people radical treatment, and had 69.6% of decreasing comparing to 2.3% of previous year, statistic difference were found（χ^2=44. 947 ,P〈0. 001）. Malaria incidence was 0.4% （8/1955） in administration villages with patients-and-relative radical treatment, with 55.6% of decreasing comparing to 0. 9% of the last year, but no statistic difference were found（χ^2= 3. 261 ,P= 0. 071）. Before October in 2007, no statistic difference were found in cumulative month malaria incidence （χ^2 = 0. 501, P = 0. 479 ） and total year malaria incidence （χ^2 = 2. 532, P = 0. 112） between two groups. Conclusion The rising trends of malaria situation could he reversed using the measure of all-people radical treatment in pre-transmission season in village with malaria incidence of over 1%, while patients-and- relative radical treatment in pre-transmission season in administrate village with malaria incidence of less 1% can effectively block the rising trends of malaria situation.