结合性雌激素软膏联合苦参凝胶对改善老年性阴道炎患者阴道微生态的作用

Gelatin Kushen improves vagina microenvironment in patients with senile vaginitis

目的探讨结合性雌激素软膏联合苦参凝胶对老年性阴道炎患者阴道微生态的影响。方法将67例老年性阴道炎患者按挂号单号码分为观察组33例和对照组34例。对照组给予结合性雌激素软膏0．5—1．0g涂抹外阴及阴道口，1次／d，连续用药16d；观察组采用与对照组相同用药8d，然后采用苦参凝胶1支／d，连续用药8d。分别于治疗前、治疗后7d和30d分别采用阴道分泌物涂片进行阴道乳酸杆菌半定量检测。结果治疗前对照组阴道乳酸杆菌阳性率48．4％（15／31），观察组为50．0％（15／30），2组差异无统计学意义（P=0．716）；治疗后7d对照组阴道乳酸杆菌阳性率74．2％（23／31），观察组为86．7％（26／30），2组差异无统计学意义（P=0．562）；治疗后30d对照组阴道乳酸杆菌阳性率80．6％（25／31），观察组为96．7％（29／30），差异有统计学意义（P=0．023）。结论结合性雌激素软膏联合苦参凝胶治疗老年性阴道炎可明显改善阴道微生态。

Objective To observe the changes of vagina microenvironment in senile vaginitis treated with gelatin Kushen. Methods Sixty-seven cases of senile vaginitis were treated with premare or premare combined with gelatin Kushen. After adopting vaginal fluid smear, Gram＇s stain examination was applied to determine the half value of vaginal lactobacilli before treatment, 7 days and 30 days after treatment. Results The detectable rates of vaginal lactobacilli were similar before treatment between the 2 groups （P = 0.716）. Seven days after treatment, the rate was slightly high in observation group（P =0. 562） . However, 30 days after treatment the rate was higher in observation group than that in control group （ P = 0. 023 ）. Conclusion Premare combined with gelatin Kushen can improve vagina microenvironment.