肿瘤标志物CEA、TSGF联合检测对胸腔积液鉴别诊断的意义

Significance of combined assays of tumor marker CEA and TSGF for differential diagnosis of pleural effusion

目的:探讨肿瘤标志物联合检测在良、恶性胸腔积液鉴别诊断中的临床意义。方法:采集有胸腔积液患者的血清和胸腔积液样本各165例,其中,恶性胸腔积液患者55例,良性胸腔积液患者110例,用化学发光法检测患者血清和胸腔积液CEA、TSGF的含量。结果:恶性胸腔积液组血清CEA、TSGF的阳性率分别为58.82%和54.29%,胸腔积液CEA、TSGF的阳性率分别为75.76%和70.67%;其中,肿瘤标志物CEA、TSGF血清及胸腔积液的阳性率明显高于良性胸腔积液组,差异有高度统计学意义(P<0.01);两组含量的检测也得出相似的结果。联合检测血清CEA、TSGF诊断恶性胸腔积液的敏感度为85.71%,特异度为97.80%。结论:肿瘤标志物CEA、TSGF联合检测,对胸腔积液的鉴别诊断有较好的临床价值。

Objective： To study the clinical significance of tumor markers combined assay in the differential diagnosis of pleural effusion. Methods： 165 serum and hydrothorax samples were collected from 165 inpatients with pleural effusion. A- mong them, 55 patients were suffered with malignant pteural effusion, and 110 patients with benign pleural effusion. The concentration of carcino-embryonic antigen （CEA）, and tumor specific growth factor （TSGF） were determined by chemilu- minescence assay. Results： In malignant pleural effusion group, the positive rates of serum CEA and TSGF were 58.82% and 54.29% respectively, the positive rates of hydrothorax CEA and TSGF were 75.76% and 70.67% respectively. Among them, CEA and TSGF in malignant group were significantly higher than those in benign pleural effusion group （P〈0.01）. The content detection also showed similar results. The sensitivity of combined assay with serum TSGF in diagnosing malignant pleural effusion was 85.71%, with the specificity of 97.80%. Conclusion： Tumor markers of CEA and TSGF have high clinical values in the differential diagnosis of pleural effusion. The combined assay with TSGF is recommended.