Ge-132与稀土离子的配合物及其对单核苷酸磷酯键的催化水解作用

Rare Earth Complexes with Ge-132 and Their Catalytic Hydrolysis to Phosphatide Bond of Mononucleotide

Ge－132的羧酸阴离子与稀土离子螯合配位，生成3：1型配合物。在配合物中，Ge－132的GeO3/2基因水解为Ge（OH）3，并且不参与稀土配位，系列稀土离子配合物的结构性质基本相同，在50℃，pH值为6的水溶液中，该配合物选择性地催化5’－AMP或5’－dAMP的磷酯键水解断裂，生成相应的核苷和磷酸，而不影响碱基与戌糖之1间的苷键。

The complexes of a series of rare earths with Ge-132 have been prepared.The carboxyl an-ions of Ce-132 molecule were coordinated to rare earth ion with chelate style.In the complexes molecule,the GeO3/2 group of Ge-132 were hydrolyzed to become Ge (OH)3 group,and later does not coordinate with rare earth ions.All of the complexes possess similar properties.In aqueous solution of pH 6 and 50℃,these complexes can obviously selectively cataliticly hydrolize the phosphatide bond in to phosphoric acid and riboside.