生津利咽含片的急性毒性实验

Acute Toxicity Test on Shengjin Liyan Lozenges

目的:观察生津利咽含片7 d内连续最大剂量灌胃给药后小鼠的急性毒性反应及死亡情况。方法:给SPF级昆明种小鼠灌服生津利咽含片,未测出LD50,故作最大给药量测试。结果:测得最大给药量为120.0 g/kg,相当于60 kg成人日用量的1 446倍。结论:生津利咽含片灌胃给药后,小鼠无急性毒性反应。

To observe the acute toxicity reaction and the death status of mice administered with the most tolerance dose of Shengjin Liyan. Lozenges consistently for 7 days by gavage. Method： Kunming SPF mice were administered with Shengjin Liyan Lozenges. Since no LD50 was found in mice, they were administered with the most tolerance dose. Result： The most tolerance dose was 120.0g/kg, which was equivalent to 1.446 times of 60kg edult＇s daily dosage. Conclusion： Mice have no acute toxicity reaction after the gastric perfusion of Shengjin Liyan Lozenges.