正常新生儿及婴儿睡眠振幅整合脑电图分析

Amplitude-integrated EEG in normal sleeping neonates and infants

为研究振幅整合脑电图(aEEG)在脑发育过程中的变化规律,根据87例无特殊疾病的新生儿和婴儿的睡眠脑电数据绘制aEEG图形。分析aEEG随受孕后年龄(PMA)增加的变化趋势。结果表明,PMA极小新生儿的aEEG呈现高度非连续性;约27周后可从aEEG波形中发现睡眠周期;37周后睡眠周期表现为高、低幅值顺次相接的波谱带。aEEG上、下边缘随PMA的增加呈上升趋势,其中脑电波幅升高较明显的年龄阶段为PMA<33周以及PMA>44周。aEEG能够反映新生儿脑发育成熟度,在临床领域有一定的应用价值。

The aEEG tracings of 87 neonates/infants （PMA = 25 60 weeks） were assessed to evaluate the variations of the aEEG （amplitude-integrated EEG） as a function of the PMA （postmenstural age）. The results show that the aEEG characteristics are closely related with the PMA. Cyclical variations of the aEEG during sleeping appeared as early as 27 weeks＇ PMA and maturated after a7 weeks＇ PMA. The upper and lower margins of the aEEG signals increased quickly for PMA below 33 or above 44 weeks with the amplitude increases slowing during 33 and 44 weeks. Thus, the aEEG is a reliable tool for evaluating the cerebral maturity of newborns.