摘要
目的测定(+)-顺丁烯二酸单冰片酯的解离常数(pKa)。方法利用紫外分光光度法及A-pH曲线法测定(+)-顺丁烯二酸单冰片酯解离常数。结果紫外分光光度法测得(+)-顺丁烯二酸单冰片酯的pKa为9.64±0.16,A-pH曲线求得pKa为9.55。结论(+)-顺丁烯二酸单冰片酯呈弱酸性,该实验结果可为(+)-顺丁烯二酸单冰片酯进一步的研究提供依据。
Objective To determine the dissociation constant of ( + ) - bornyl monomaleate. Methods The dissociation constant of ( + ) - bornyl monomaleate was detected by ultraviolet (UV) spectrophotometry and A - pH curves. Results The dissociation constant of ( + ) - bornyl monomaleate was 9.64 ± 0.16 evaluated by UV and 9.55 by A - pH curves. Conclusion ( + ) - bornyl monomaleate is a weak acid. The result will supply evidence for the further research of ( + ) - bornyl monomaleate.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2009年第2期147-149,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家高新技术研究发展计划(863计划)资助项目子课题(2002AA2Z3421)
国家自然科学基金资助项目(K1070026)