降脂汤治疗脂质代谢紊乱(痰瘀互阻型)的临床研究

Clinical Study on Jiangzhi Decoction in Regulating Lipometabolic Disorder with Stagnation of Phlegm and Blood-stasis

目的探讨降脂汤治疗脂质代谢紊乱的临床疗效。方法以脂必妥胶囊为对照药,进行随机、阳性药物平行对照临床试验。共纳入64例脂质代谢紊乱患者,治疗组与对照组各32例,疗程4周。结果治疗组用药后总胆固醇(TC)、甘油三酯(TG)、动脉硬化指数(AI)水平降低,高密度脂蛋白(HDL-C)水平升高,常规心电图ST下降总和明显改善,治疗前后比较均有显著性差异。治疗组患者胸胁闷痛、头晕、肢麻、纳呆及头痛等中医症状明显改善,特别是胸胁闷痛、头晕及纳呆等症状改善明显优于对照组。结论降脂汤治疗脂质代谢紊乱有良好疗效,且在改善患者临床症状方面疗效显著。

Objective To investigate the therapeutic effect of Jiangzhi Decoction （JD） for the treatment of disordered lipid metabolism. Methods With Zhibituo Capsule as the control capsule, a random, paralleled and positive controlled clinical trial was carried out. A total of 64 patients were equally randomized into the treatment group and control group, and the treatment lasted 4 weeks. Results After administration, the level of total cholesterol （TC）, triglyecride （TG）, and arteriosclerosis index （AI） were reduced, the high density lipoprotein cholesterol （HDL - C） level was increased, and the sum of the decrease of electrocar- diogram （ECG） ST segment was markedly improved in the treatment group, the difference being significant compared with those before treatment. In the treatment group, oppressive pain in the chest and hypochondrium, dizziness, limb numbness, poor ap- petite and headache were much relieved, and the relief of oppressive pain in the chest and hypochondrium, dizziness, and poor appetite was obvious as compared with the control group. Conclusion JD has good curative effect on disordered lipid metabolism with stagnation of phlegm and blood - stasis, in particular on relieving the clinical symptoms.