碳纳米材料的细胞生物效应

Cellular Biological Effects of Carbon Nanomaterials

碳纳米材料包括富勒烯如C60、金属富勒烯、碳纳米管及其衍生物等。这一类纳米材料不仅在环境和生物医学领域已有大量的基础研究成果,而且具有广泛的应用前景。因此,理解它们与细胞相互作用的过程和相互作用机制,对阐明它们的生物医学功能十分重要。尤其是这类纳米颗粒是否能够进入细胞,如何进入细胞,在细胞内的定位,以及对细胞的生物学功能有何影响,本文对这些问题,从不同的方面进行了综述和探讨。为这类纳米材料的生物医学应用提供了较为系统的基础知识。

Carbon nanomaterials include fullerenes, metallofullerenes, carbon nanotubes, and their derivatives. Their novel functions have been well investigated in basic science, and many uses/applications have been reported in the environmental and biomedical fields. Therefore, understanding the processes of their cellular interactions with living cells is of significant importance for exploiting their applications in biomedical fields. In particular, if they could enter the cell, the process of internalization, their localization in intracellular compartments, and their succedent effects on the cellular functions, the current findings for these aspects are summarized in this paper. We aim to provide the basic knowledge for people who are intereted in the development of the biomedical applications of these carbon nanomaterials.