HIF-1α在人舌鳞癌组织中的表达及意义

Expressions and Significance of HIF-1α in Human Tongue Squamous Cell Cacinoma Tissue

目的研究缺氧诱导因子-1α(HIF-1α)在舌鳞癌组织、癌旁正常舌组织中表达状况及与舌癌进展之间的关系。方法采用半定量免疫印迹法(Western blot)检测40例舌鳞癌组织和癌旁正常舌组织中HIF-1α的表达。结果HIF-1α在舌癌组织中的表达水平明显高于癌旁正常组织中的表达水平(P<0.05)。HIF-1α表达与舌癌的临床TNM分期、淋巴结转移有关(P<0.05),与性别、年龄、组织学类型无关(P>0.05)。结论HIF-1α在舌癌的进展中具有重要作用,与疾病发展进程密切相关。

Objective To investigate the expressions of hypoxia - inducible factor -1α（ HIF -1α） in Tongue squamous cell cacinoma（TSCC） tissue, and the relationship with progression of TSCC. Methods Specimins from 40 patients with TSCC and the adjacent normal tissue to tumor were collected, and expressions of HIF-1α was observerd using western blot. Results The positive expression rates of HIF-1α in TSCC tissues were significantly higher than those in the adjacent normal tissues of tongue （P 〈0.05）. Meanwhile, there were significant correlations between the expression of HIF-1α and the TNM clinical stages, lymph node metastasis（P 〈 0.05 ）, but there was no relationship with gender, age and histological type of tumor （ P 〉 0.05 ）. Conclusion HIF-1α play important roles in the progress of Tongue squamous cell cacinoma.