视黄醇结合蛋白4与多囊卵巢综合征及妊娠糖尿病

Retinol binding protein 4 and polycystic ovary syndrome and gestational diabetes mellitus

视黄醇结合蛋白4主要由肝脏合成，是血液中一种运送视黄醇的结合蛋白，亦是脂肪组织分泌的一种脂肪细胞因子。小鼠实验发现，其在组织中的过度表达可使磷脂酰肌醇3激酶活性下降，胰岛素受体底物1酪氨酸磷酸化降低，可能与胰岛素抵抗的发生有关。肥胖、糖耐量减低、胰岛素抵抗、多囊卵巢综合征、妊娠糖尿病患者血清中视黄醇结合蛋白4含量与正常者相比升高，其可能与此类疾病的发病机制有关。

Retinol binding protein 4 （RBP4） is a retinol transporting protein, secreted mainly by the liver. It is also an adipokine. Experiments in mice proved that overexpression of RBP 4 is associated with the decreased activity of phosphatidylinositol 3 kinase and tyrosine phosphorylation of insulin receptor substrate- 1, and 4 may link to insulin resistance in human. Compared with normal subjects, serum RBP4 concentration is elevated in patients with obese,impaired glucose tolerance, insulin resistance, polyeystic ovary syndrome and gestational diabetes mellitus. It may play a role in the pathogenesis of these diseases.