类胍中间体的合成及生物活性研究

Synthesis and Biological Activity of Guanidine Intermediate

噻吩嘧啶酮的稠杂环化合物具有广谱的生物活性,对于制备该类化合物的类胍中间体的合成和生物活性报道很少.通常类胍中间体无需进一步纯化,可直接进行下一步操作即制得噻吩嘧啶酮,我们合成出了类胍中间体,并对其性质和生物活性作一系统研究.

Synthesis and properties of a large number of thiophene pyrimidines heterocyclic compounds with biological activity were reported, but synthesis and biological activity of guanidine intermediate was seldom reported. Guanidine intermediate is usually no need for further purification, can be the next step is a system of thiophene pyrimidin-ones.We prepared Guanidine intermediates, and studied the properties and biological activity.