脑创伤对大鼠学习记忆功能的影响

Effect of traumatic brain injury on learning and memory of rats

目的：观察ＴＢＩ后大鼠主动性条件回避反应（ＡＣＡＲ———穿梭箱实验，ｓｈｕｔｌｅｂｏｘｔｅｓｔ）及被动性条件回避反应（ＰＣＡＲ———步入与步下实验，ｓｔｅｐｔｈｒｏｕｇｈａｎｄｓｔｅｐｄｏｗｎｔｅｓｔ）的变化。方法：用２０ｇ重物从不同高度垂直坠落至大鼠一侧暴露的硬脑膜复制脑创伤（ＴＢＩ）模型。结果：重度ＴＢＩ后大鼠ＡＣＡＲ的习得率和保持率均出现下降，ＰＣＡＲ的步入和步下潜伏期缩短；轻度ＴＢＩ后仅表现出ＡＣＡＲ的习得率降低。结论：ＴＢＩ易导致脑高级功能障碍，其受损程度与原发伤情有关。

AIM:The active conditioned avoidance responses(ACAR-shuttle box test)and passive conditioned avoidance responses(PCAR-step through and step down test) were observed after TBI.METHOD:Animal models of traumatic brain injury(TBI) were produced on rats by dropping a 20g weight from different high upon unilateral exposed dura.RESULTS: Severe TBI brought to decreases of the acquisition and retention rates of ACAR as well as reductions of the latencies of step through and step down;in mild TBI,only showed decreases of acquisition rates of ACAR.CONCLUSION:Higher brain functions were liable to be effected and the severity of TBI decided the intensity of functional damage. .