绝经前乳腺癌手术时间与预后的关系

Timing of surgery in relation to the prognosis in prmenopausal women with breast cancer

目的：探讨绝经前女性乳腺癌预后与手术时间的关系。方法：以１９８０年至１９８６年我院２６４例可手术绝经前乳腺癌病人为分析对象，初次手术于末次月经第一天始至第１２天为卵泡期组，于末次月经第１２天以后为黄体期组，采用ＢＭＤＰ计算软件进行统计分析。结果：卵泡期组比黄体期组１０年生存率有明显差异（３６２８％比８０７８％Ｐ＝０００１）。两组病例中淋巴结阴性和阳性者１０年生存率比较均有显著性差别。结论：进行乳腺癌的时机化手术是改善绝经前妇女乳腺癌预后的途径之一。

Purpose: To study the timing of surgery in relation to the menstrual cycle in premenopausal women with breast cancer. Methord: The date of 264 premenopausal patients who underwent primary surgery for operable breast cancer between 1980 and 1986 were analsed. Patients whose initial surgery was 1-12 days after the starting date of the last menstrual period were divided as folicular phase group and those underwent operation more than 12 days after the last menstruation were luteal phase group. The survival rate were obtained using BMDP statistical analysis. Result: At 10 years, overall survival rate of folicular phase group was significantly poorer compared with luteal phase group (36.28 versus 80.78 percent, P=0.001) These differences in survival remained significant in patients with negative or positive axillary nodes between this two groups. Conclusions: The study provides evedence that timing of surgery in relation to the menstrual cycle may be one of the best way to increase the survival rate in premenopausal women with breast cancer. Prspective studies are required to elucidate the relationship between the timing of all surgical procedures during the menstrual cycle and survival.