左旋卡尼汀对维持性血液透析患者生活质量和贫血的影响

Effects of L-carnitine on health-related quality of life and anemia in maintenance hemodialysis patients

目的探讨左旋卡尼汀对维持性血透（MHD）患者生活质量和贫血的影响。方法将30例维持性血透患者随机分为治疗组（15例）和对照组（15例）。两组透析结束后均使用重组人促红细胞生成素（rhFPO）3000IU皮下注射2～3次／周，而治疗组每次透析后加静脉注射左旋卡尼汀1g。随访12周，分别在治疗前及治疗12周末给两组患者应用SF36系统进行生活质量评分并检测血红蛋白、红细胞压积、血浆白蛋白的情况。结果治疗后治疗组患者的生活质量评分较治疗前有明显的上升，较对照组治疗后亦有明显的增高，差异均有统计学意义（P〈0．01）；治疗组的血红蛋白、血细胞比容、血浆白蛋白水平显著高于对照组，差异有统计学意义（P〈0．01）。结论静脉注射左旋卡尼汀可明显提高维持性血透患者生活质量和促进改善维持性血液透析患者的贫血。

Objective To investigate the effect of L-carnitine on quality of life and anemia in maintenance hemodialysis（MItD） patients. Methods Thirty MHD patients were randomly divided into treatment group（ n = 15） and control group（ n = 15）. All of the patients were received 30001U of rhEPO subcutaneous injection, 2 to 3 times a week after hemodialysis. In treatment group, 1.0g of L earnitine was infused to the patients at the end of each dialysis treatment for 12 weeks. SF36（ Short Form with 36 questions）score about LQ were recorded and analyzed. Hb, Hct and Alb were measured before and after treatment. Results In treatment group each item was significantly increased after treatment （P 〈 0.05 ） while no significant changes was found in control group. Conclusion Using L-camitine may improve quality of life and anemia in MHD patients.